What is Celecoxib Powder
Celecoxib Powder is a nonsteroidal antiinflammatory drug (NSAID) first launched as Celebrex in the US for the treatment of symptoms in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Celecoxib belongs to a new class of 1, 5-diarylpyrazoles and can be synthesized by heat-promoted heterocyclization of a trifiuoro-l,3-dione with appropriate arylhydrazine. Celecoxib is a highly selective inhibitor of COX-2, the inducible form of cyclooxygenase expressed during inflammatory processes; it does not block the constitutive form COX-1, thus suppressing the gastric and intestinal toxicity of most non-selective NSAIDs. The potency ratio COX1/COX2 on purified human enzymes was about 400. In several in vivo models of acute and chronic inflammation, Celecoxib demonstrated potent antiinflammatory activity without affecting gastric or urinary prostaglandin PGE2. In several clinical studies performed with patients suffering from osteoarthritis or rheumatoid arthritis, Celecoxib was shown to be well tolerated and to relieve pain and inflammation more efficiently compared with other standard NSAIDs; the gastrointestinal safety profile was significantly better than that of other NSAIDs. Interestingly, Celecoxib was approved for another indication in patients with familial adenomatous polyposis (FAP). A six-month clinical trial demonstrated a 28% reduction in the number of colorectal polyps with Celecoxib, compared to a 5% reduction with placebo.
Coa of Celecoxib Powder
ANALYSIS | SPECIFICATION | RUSULT |
---|---|---|
Assay(HPLC) | 99.0%MIN | 99.66% |
Identification | Positive reaction | Conform |
Loss on drying | 5.0%MAX | 3.8% |
Reside on ignition | 0.1%MAX | 0.04% |
Heavy Metal | 10ppmMAX | Conform |
Melting range | 161-164C | 164C |
Particle siae | 98% pass 80 mesh | Conform |
Melantine | Negative | Negative |
Total plate count | 1000cfu/g | Conform |
Mold | 300cfu/g | Conform |
E.Coli | Negative | Negative |
Salmonella | Negative | Negative |
Pseudomonas | Negative | Negative |
Staphylococcus | Negative | Negative |
What diseases can celecoxib Powder be used to treat?
What symptoms can celecoxib powder be used to relieve?
It is mainly used to relieve symptoms and signs of osteoarthritis, relieve pain and primary dysmenorrhea.
What drugs are commonly used with celecoxib powder?
Rheumatoid arthritis: Celecoxib can relieve inflammatory symptoms in the acute stage of gout, but it cannot eradicate the cause of inflammation. It should be combined with anti-rheumatic drugs (including methotrexate, leflunomide, sulfasalazine, elamod, hydroxychloroquine, etc.) to eliminate the cause as soon as possible.
Who is strictly prohibited from using celecoxib powder?
Which drugs will celecoxib powder interact with?
Contact US
If you want to buy Celecoxib powder please contact us for more details iceyqiang@aliyun.com